Publications

2020

Intact Olfactory Memory in the 5XFAD Mouse Model of Alzheimer’s Disease From 3 to 15 Months of Age

O’Leary TP, Mantolino HM, Stover K, Darvesh S, Brown RE. 2020. Intact olfactory memory in the 5XFAD mouse model of Alzheimer’s disease from 3 to 15 months of age. Behavioural Brain Research. 393: 112731. PMID: 32522622.

Is Inhaled Furosemide a Potential Therapeutic for COVID-19?

Brennecke A, Villar L, Wang Z, Doyle LM, Meek A, Reed M, Barden C, Weaver DF. Is Inhaled Furosemide a Potential Therapeutic for COVID-19? Am J Med Sci. 2020 Sep;360(3):216-221. doi: 10.1016/j.amjms.2020.05.044. Epub 2020 Jun 1. PMID: 32622469.

The Brain Exposure Efficiency (BEE) Score

Gupta M, Bogdanowicz T, Reed MA, Barden CJ, Weaver DF. The Brain Exposure Efficiency (BEE) Score. ACS Chem Neurosci. 2020 Jan 15;11(2):205-224. doi: 10.1021/acschemneuro.9b00650. Epub 2019 Dec 27. PMID: 31815431.

Small Molecule Therapeutics for COVID-19: Repurposing of Inhaled Furosemide

Wang Z, Wang Y, Vilekar P, Yang SP, Gupta M, Oh MI, Meek A, Doyle L, Villar L, Brennecke A, Liyanage I, Reed M, Barden C, Weaver DF. Small molecule therapeutics for COVID-19: repurposing of inhaled furosemide. PeerJ. 2020 Jul 7;8:e9533. doi: 10.7717/peerj.9533. PMID: 32704455; PMCID: PMC7350920.

2019

The Novel Small Molecule TRVA242 Stabilizes Neuromuscular Junction Defects in Multiple Animal Models of Amyotrophic Lateral Sclerosis

Bose P, Tremblay E, Maois C, Narasimhan V, Armstrong GAB, Liao M, Parker JA, Robitaille R, Wen XY, Barden C, Drapeau P. The Novel Small Molecule TRVA242 Stabilizes Neuromuscular Junction Defects in Multiple Animal Models of Amyotrophic Lateral Sclerosis. Neurotherapeutics. 2019 Oct;16(4):1149-1166. doi: 10.1007/s13311-019-00765-w. PMID: 31342410; PMCID: PMC6985319.

Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice

Fertan E, Stover KRJ, Brant MG, Stafford PM, Kelly B, Diez-Cecilia E, Wong AA, Weaver DF, Brown RE. Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice. Front Pharmacol. 2019 Sep 24;10:1044. doi: 10.3389/fphar.2019.01044. PMID: 31607909; PMCID: PMC6773979.

The Blood–Brain Barrier (BBB) Score

Gupta M, Lee HJ, Barden CJ, Weaver DF. The Blood-Brain Barrier (BBB) Score. J Med Chem. 2019 Nov 14;62(21):9824-9836. doi: 10.1021/acs.jmedchem.9b01220. Epub 2019 Oct 25. PMID: 31603678.

Chapter Eleven - Misfolded Proteins as a Therapeutic Target in Alzheimer's Disease

Liyanage SI, Weaver DF. Misfolded proteins as a therapeutic target in Alzheimer's disease. Adv Protein Chem Struct Biol. 2019;118:371-411. doi: 10.1016/bs.apcsb.2019.08.003. Epub 2019 Sep 21. PMID: 31928732.

2018

Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold

Brant MG, Goodwin-Tindall J, Stover KR, Stafford PM, Wu F, Meek AR, Schiavini P, Wohnig S, Weaver DF. Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold. ACS Med Chem Lett. 2018 Jan 11;9(2):131-136. doi: 10.1021/acsmedchemlett.7b00488. PMID: 29456801; PMCID: PMC5807880.

Phenylpropanoids and Alzheimer's Disease: A Potential Therapeutic Platform

Kolaj I, Imindu Liyanage S, Weaver DF. Phenylpropanoids and Alzheimer's disease: A potential therapeutic platform. Neurochem Int. 2018 Nov;120:99-111. doi: 10.1016/j.neuint.2018.08.001. Epub 2018 Aug 8. PMID: 30098379.

The Hidden Variables Problem in Alzheimer's Disease Clinical Trial Design

Liyanage SI, Santos C, Weaver DF. The hidden variables problem in Alzheimer's disease clinical trial design. Alzheimers Dement (N Y). 2018 Nov 13;4:628-635. doi: 10.1016/j.trci.2018.09.003. PMID: 30519628; PMCID: PMC6260222.

Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation

Mancini RS, Wang Y, Weaver DF. Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation. Front Neurosci. 2018 Oct 12;12:735. doi: 10.3389/fnins.2018.00735. PMID: 30369868; PMCID: PMC6194148.

Tauopathy in the APPswe/PS1ΔE9 Mouse Model of Familial Alzheimer’s Disease

Metaxas A, Thygesen C, Kempf SJ, Anzalone M, Vaitheeswaran R, Petersen S, Landau AM, Audrain H, Teeling JL, Darvesh S, Brooks DJ, Larsen MR, Finsen B. 2018. Tauopathy in the APPswe/PS1ΔE9 mouse model of familial Alzheimer’s disease. bioRxiv. 405647.

In the Alzheimer Waiting Room

Weaver DF. In the Alzheimer waiting room. CMAJ. 2018 Aug 20;190(33):E989-E990. doi: 10.1503/cmaj.180320. PMID: 30998498; PMCID: PMC6102110.